* {
  box-sizing: border-box;
}

html, body {
    margin: 0px;
    padding: 0px;
    font-family: 'Trebuchet MS', 'Lucida Sans Unicode', 'Lucida Grande', 'Lucida Sans', Arial, sans-serif;
    background-color: rgb(215, 215, 215);
  }


#toolname {
  margin: 20px 110px 0px;
  padding: 0px;
}


#page-logo {
  display: inline-block;
}

.menu {
  display: inline-block;
}

#SPASE-mini-logo {
  display: inline-block;
  height: 50px;
  margin:0px;
  padding:15px;
}



#INRS-logo{
  margin: 10px 10px;
  height: 30px;
  padding:0px;
}





.main-menu{
  margin: 12px 0px 0px;
  float:left;

}

.header {
    top:0px;
    left:0px;
    right:0px;
    height: 50.3px;
    text-align: center;
    position: fixed;
    width: 100%;
    background: #101a21;
    z-index: 10;
    min-width: 800px;
  }

.menu-item {
    font-size: 20px;
    color:white;
    margin: 0px;
    padding:15px;
    text-decoration:none;
  }

.menu-item:hover, #user-guide:hover {
    color:black;
    text:bold;
    background-color: #c0d6ff;
  }

  #user-guide
  {
    color:black;
    font-size: 20px;
    background-color: #3d6ec9;
    margin: 0px;
    padding:15px;
    text-decoration: none;
  } 

  .mini-logo-container {
    background-color: transparent;
    display: inline-block;
    float: left;
    height:50px;
  
  }

 .mini-logo-container:hover {
  background-color: #c0d6ff;
 } 

#SPASE-mini-logo:hover {
    filter:brightness(0%);
  }

  .footer {
    position:fixed;
    margin: 0px;
    bottom:0px;
    left: 0px;
    right:0px;
    width: 100%;  
    height: 30px;
    background-color: #101a21;
    z-index: 10;
  }
  
  .footer-note {

    display: inline-block;
    padding: 2px;
    margin:7px 12px;
    color:white;
    z-index: 11;
    max-width: 50%;
    left: 0px;
    position: fixed;
  }

  .contact-us {
    display: inline-block;
    position:fixed;
    padding: 2px;
    margin:7px 12px;
    color:white;
    z-index: 12;
    text-align:right;
    position: fixed;
    right: 0px;
  }


  /* end of header and footer */

  main {
      margin: 100px 200px;
    }

    #main-title {
      display: block;
      font-weight:1000;
      font-family: 'Gill Sans', 'Gill Sans MT', Calibri, 'Trebuchet MS', sans-serif;
      width: 100%;
      padding: 0px;
    }

    .titles {
      padding:0px;
      margin: 0px;
      font-weight: 900;
    }

    #general-pipeline {
      font-size: 0.8vw;
      padding: 0px;
      margin: 0px;
    }

    .tiles {
      display: relative;
      background-color: darkgray;
      padding: 30px;
      margin: 0px 0px 50px;
      border-radius: 10px;
      min-width: 500px;
      height: auto;
    }

    .tile-content {
      display: flex;
      align-content: space-between;
      margin: 20px 0px;
      flex-direction:column;
      gap: 20px;
      flex-wrap: nowrap;
    }

    .line1, .line2 {
      display: flex;
      flex-direction:row;
      height:auto;
      align-items: flex-start;
    }

    .left-content {
      display: flex;
      flex: 1 1 40%;
      min-width: 300px;
      height:auto;
    }

    .right-content {
      display: flex;
      flex: 1 1 60%;
      margin: 0px 0px 0px 50px;
      font-size: 0.9vw;
      flex-direction:column;
    }

    .right-content h3 span {
      font-weight:lighter;
    }

    .right-content h3 b {
      color:darkred;
    }

    .pdbfixer-block {
      font-size: 1vw;
    }

    .example-image {
      width: 100%;
      height: auto;
      border: 2px solid #0053c8;
      border-radius: 5px;
      display: block;
      min-width: 300px;
    }

    .out-line1 {
      display:flex;
      justify-content: space-between;
      flex-wrap: wrap;
      text-align: center;
      margin-top: 20px;
      align-items: flex-start;
    }

    .out-line1-items {
      flex: 1 1 20%;
      align-content: center;
      text-align: center;
      flex-wrap: wrap;
      min-width: 400px;
      margin: 25px;

    }

    .out-example-image {
      padding: 20px;
      max-width: 100%;
      height: 400px;
      background-color: white;
      padding: 0px;
      border-radius: 5px;
      border: solid 2px #0053c8; 
    }



    #out-files-divider {
      display: block;
      width: 90%;
      margin: 0 auto;
    }

    .out-files {
      width: 100%;
      margin: auto;
      text-align: center;
      align-content: center;
      border-radius: 5px;
      border: solid 2px #0053c8;
      padding:20px;
      background-color: white;
    }

    .bottom-lines {
      margin: 0px 100px;
    }